" The right to be God. That right... is now mine! "

The origins and early history of the life of Albert Wesker are a mystery, with it remaining unknown if he has relatives alive today, or what motivated him to join the dark side of life.

Whatever the case, Wesker joined the international pharmaceutical enterprise Umbrella Corporation, at the age of 17 and began working as one of its researchers. In 1977, Wesker was assigned to the Management Training Facility under Doctor James Marcus. Wesker became friends with fellow trainee William Birkin, becoming colleagues and accomplices for years to come. Both Wesker and Birkin were regarded by Marcus as his best apprentices, and when the Training Facility was closed down on July 29, 1978, the two were personally transferred to the Arklay Research Laboratory (underneath Ozwell E. Spencer's estate) to continue their own t-virus research (while Marcus continued to work on his own), becoming the facility's chief researchers.


Wesker and Birkin's research of the t-virus lasted over 13 years and three different stages. In 1988, when the research reached its third stage (the creation of the Tyrant bio-weapon), Wesker and Birkin were then ordered by Spencer to assassinate their former mentor, Marcus and steal all of his research. Shortly after, Birkin's research yielded the discovery of the G-virus in Lisa Trevor's body. When Spencer approved his project in 1991, Wesker began having doubts about Spencer's intentions and requested a transfer to Umbrella's Intelligence Bureau that same year.

In 1996, Wesker formed the Raccoon City Police Department's S.T.A.R.S. unit and served as its captain and as leader of one of its two squads, Alpha Team. Two years after the formation of S.T.A.R.S., a series of homicides occurred near the Arklay region. While the public feared these deaths were the work of a local cult, only Wesker knew the truth. In an effort to control the public outcry, S.T.A.R.S. Bravo Team was dispatched to the region to investigate the situation. Wesker used the time they were gone as an opportunity to gather battle data by pitting the members of S.T.A.R.S. against Umbrella's Bio-Organic Weapons (B.O.W.s).

The following day, all contact with Bravo Team was lost and Wesker's Alpha Team was dispatched to the site. Upon arrival, Alpha Team was attacked by Cerberus and then, abandoned by their pilot, Brad Vickers. After the loss of member Joseph Frost to the dogs, Wesker and the remaining members of Alpha Team sought refuge in the nearby mansion, where Wesker had previously worked. Initially ordering everyone to split up, Wesker disappeared and left the remaining members of Alpha Team (Chris Redfield, Jill Valentine and Barry Burton) to fend for themselves. Wesker probably gained access to a secret area or had the master key of the mansion in order to disappear for a great part of events that the other members of S.T.A.R.S. witnessed. Some fans believe that he monitored the battles between the remaining S.T.A.R.S. operatives and the creatures that infested the mansion from an undisclosed "secret" area.

Of the nine S.T.A.R.S. operatives who entered the mansion (including Wesker himself), only the members of Alpha Team, along with Bravo Team's Enrico Marini and Rebecca Chambers, managed to survive against the various creatures and bio-organic weapons that infested the facility. In order to ensure the downfall of the other members, Wesker used extortion in order to convince Barry to do his bidding (luring the others to traps) by threatening his family. When Enrico uncovered evidence that implicated Wesker and Umbrella, Wesker murdered Enrico (it has been stated that Wesker ordered Barry to perform the actual murder, though this is false because he is with Jill in her storyline.) However, Chris and Jill learned the truth about Wesker and then, proceeded to foil his plot by destroying the T-002 Tyrant, along with the facility itself.

During the ensuing chaos, Wesker injected himself with an possible variant of the G-Virus given to him by his partner, William Birkin. After allowing the Tyrant to kill him, the virus reanimated his body. This gave him superhuman strength, agility and regeneration, but at the severe cost of the loss of his humanity. The resulting mutation also gave him gold-red cat-like eyes (but these are not immediately noticeable, due to the sunglasses he always wears). Wesker was revived, while Umbrella and the remaining S.T.A.R.S. operatives were convinced that he died in the explosion. Realizing the S.T.A.R.S. had destroyed the Tyrant and escaped with their lives, he swore revenge against the remaining S.T.A.R.S. members. His plan to leave no shred of evidence behind had been foiled. He wanted to avoid suspicion cast in his direction, so as not to expose his long-past machinations to scrutiny from Umbrella. Regardless, when the remaining S.T.A.R.S. attempted to go public with what they knew, though disbelieved by the public, Umbrella was very interested in Wesker's betrayal. Eventually, they began to suspect Birkin as well, and planned to have him assassinated and his G-virus projects seized (after Birkin decided to leave Umbrella and sell his work directly to the U.S. Government, instead). Wesker knew this and began to prepare to head off Umbrella.

Using data he recorded, Wesker was able to secure a high-ranking employment position within one of Umbrella's mysterious rivals; The Agency, and began spying on Umbrella's activities. When Raccoon City suffered a t-virus outbreak, Wesker hired and sent a private agent named Ada Wong to retrieve the G-virus sample in the (unknowing) possession of William's only daughter Sherry Birkin, hidden within her pendant. While Ada lost the sample, she was able to secure another sample of the virus from William's remains (William had transformed into a monstrous creature after injecting himself with the virus, and as such was defeated by both Leon and Claire), but then lost the other sample to Umbrella Special Service (USS) Alpha Team Leader (and sole surviving operative) HUNK, who was also sent from Umbrella's Paris Branch to secure a sample of the virus. After the Incident, Wesker, wanting to know about what other secrets Sherry might be hiding on her late father's behalf, had the Agency's spies in the U.S. Government keep watch over her. Wesker, who never underestimated Birkin, eventually had Sherry taken into custody and imprisoned, believing there was something more to her than met the eye.

Wesker and the Hive/Host Capture Force (HCF), a heavily armed Agency Special Forces Team, attacked the Umbrella facility on Rockfort Island, intent on retrieving a sample of the T-Veronica virus virus, created on Rockfort by Umbrella Chief Researcher Alexia Ashford. The attack succeeded, especially when the t-virus samples and captive B.O.W's in the laboratory section of the facility broke containment and contaminated the Island. However, Wesker and his men failed to find the missing Alexia. Wesker then went to the Antarctic Research Facility, which had also suffered a t-virus outbreak from infected Rockfort employees fleeing to the facility. It was here Wesker encountered his former subordinate Chris Redfield (who had arrived seeking his missing sister Claire). Wesker failed to gain a sample of the virus from Alexia, especially when he tried to use his own abilities to force her to surrender one, only to be driven back by Alexia's own abilities. While Chris fought and killed Alexia, Wesker was able to secure a sample of the virus from the retrieved corpse of Steve Burnside.

The base started its self-destruct sequence, but Wesker engaged Chris in combat, eager to settle the score. Wesker quickly used his immense strength and speed to gain dominance, with Chris refusing to allow Wesker an easy kill. Wesker was poised to deliver the finishing blow, only for an explosion, caused by the priming self-destruct, to knock a flaming pillar in between the two. Wesker, vowing Chris was lucky and next time they met he couldn't count on luck again, escaped the base as it began to crumble and explode around them. Wesker reached an Agency Submarine and sailed away. While the flaming pillar had badly burned Wesker's face, his burns healed no more than five minutes later due to his superhuman regenerative capabilities.

In 2003, Wesker infiltrated the Russian Umbrella Facility and managed to kill the mutated Sergei Vladimir. He then took Umbrella data from the Red Queen, before deleting the computers memory, shutting down the facility. Shortly thereafter, finally having strong evidence against Umbrella, he brought his findings to the court. With information from Wesker (who operated under the pretence of being a personal friend of the CEO), Umbrella was found guilty and officially shut-down, its top officials suffering legal troubles and an international manhunt began for Ozwell E. Spencer.

Following the fall of Umbrella, Wesker soon proved to be a problem for his Agency superiors. Wesker had always cherished a desire for power, prominence and domination over others, and, seeing Umbrella as power incarnate, used it to hide behind while he made plans of his own. When Umbrella folded, and the sanctuary and protection it provided ruined by the surviving Umbrella leaders' constant power struggles, Wesker sought to resurrect Umbrella in his own way under his leadership. To this end, he contacted the "S" Corporation, and has been in contact with them following Umbrella's demise, serving as one of their operatives. The Agency was aware of this however, and, suspicious and remaining ever vigilant, ordered Ada Wong to pretend to work with him during the affair with los Illuminados, and then ordered her to supply Wesker with a false las Plagas sample, after stealing a real sample from the cult's leader Osmund Saddler. Wesker wasn't fooled, however, as he knew exactly what the Agency is thinking, and will most likely see through the deception soon. What will happen then is unknown.